Magnesium sulphate as a treatment of acute attack of multiple sclerosis

Abstract

The blood-brain barrier (BBB) is a complex organization of cerebral endothelial cells. Deregulation of the BBB is among the earliest cerebrovascular abnormalities seen in multiple sclerosis (MS).
Magnesium sulfate has been shown to have a protective effect on BBB integrity in multiple experimental models. Magnesium sulphate attenuates BBB permeability. Also, results of light microscopy and electron microscopy verified that magnesium sulfate can attenuate BBB injury. I suggest using of MgSO4 which attenuates BBB permeability during acute relapses of MS. The hypothesis should be assessed in several experimental and clinical trials. If my hypothesis can be verified experimentally and clinically, then using Mg sulphate to treat MS disease could be achieved.