Modified retention enema, possible cure for solitary rectal ulcer

Abstract

Since ancient times, enemas have been used in various clinical scenarios. It was used as a way to relieve constipation, administration of analgesia and anesthesia in children, pre-operative bowel preparation, control of fever and seizures, post-operative analgesia, and the treatment of acute pancreatitis, hepatic encephalopathy and hyperkalemia.
We believe clinical application of this modified retention enema can benefit patients suffering from solitary rectal ulcer syndrome (SRUS).
Our hypothesis is to prove superiority of combination therapy to conventional therapies for Mucosal Prolapse Solitary Rectal Ulcer Syndrome (MPSRUS). Our modified retention enema has active components that improve inflammation, protects mucosa and explained method of administration will also improve mucosal blood perfusion. This will result in clinical and histological healing of the SRUS.