Could Low Level Laser Irradiation improve the function of isolated islets before transplantation?

Abstract

Pancreas islet transplantation is one of the potential cure for type 1 diabetes. However Current isolation techniques lead to loss of number and function of isolated islets during procedure, needing in any cases two donors for each transplant. To overcome this problem many factors and added extra protocols should be investigated during isolation process. Low level laser irradiation (LLLI) is currently being used to treat wide variety of medical conditions. Many studies have proved cellular proliferation after in-vitro irradiation of low level laser. Effects of LLLI in secretory cells have been also considered. It has been shown that products of these cells are amplified after irradiation. These effects on LLLI are explained by increasing intracellular ATP and Ca2+ flux. Based on these findings, it can be hypothesized that low level laser could be beneficial for islet viability and function, if it irradiates to islets during isolation procedure.